Your mission, should you choose to accept it, is to reproduce major findings of a Science paper in just 60 seconds.
This recipe is based on a fun diversion that I show during lectures. The goal of the recipe is to demonstrate that, when properly documented it is possible to reproduce major scientific findings with relative ease and perhaps under a minute.
This recipe reproduces the main results published in the work:
On a properly set up system, and depending on bandwidth, the recipe completes under a minute. This includes getting the data, references, aligning and calling variants! The results even include annotations of the variant effects relative to the features on the genome.
The best way to enjoy this analysis is to have the following video playing while the analysis is running:
Note how this theme song makes even the otherwise bland analysis feel super exciting.